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'Snowflake' The Albino Gorilla

'Snowflake' The Albino Gorilla
A famous albino gorilla that lived for 40 years at the Barcelona Zoo got its white coloring by way of inbreeding, new research shows.

Snowflake was a male Western lowland gorilla. He was born in the wild and captured in 1966 by villagers in Equatorial Guinea. As the only known white gorilla in the world, Snowflake was a zoo celebrity until his death of skin cancer in 2003.

A few studies had attempted to get to the bottom of what caused Snowflake's color-free complexion, but the exact genetic mutation had never been found. Now, Spanish researchers have sequenced the gorilla's entire genome, revealing that Snowflake was probably the offspring of a pairing between an uncle and a niece.

Explaining albinism

In humans, four genetic mutations are known to cause albinism, a syndrome marked by a lack of skin, eye and hair pigment. People with albinism are at high risk for vision problems and skin cancers because of this missing pigment.

Using frozen blood from Snowflake, researchers led by Tomas Marques-Bonet of the Institut de Biologia Evolutiva at the University of Pompeu Fabra sequenced the entire genome of the late ape. Comparing that sequence with those of humans and nonalbino gorillas, Marques-Bonet and his colleagues narrowed down the cause of Snowflake's albinism to a single gene, known as SLC45A2. Snowflake inherited a mutant form of this gene from both of his parents.

The gene has previously been linked to albinism in mice, horses, chickens and a species of fish.

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